Delay in diagnosis of influenza A (H1N1)pdm09 virus infection in critically ill patients and impact on clinical outcome.
Identifieur interne : 000157 ( Main/Exploration ); précédent : 000156; suivant : 000158Delay in diagnosis of influenza A (H1N1)pdm09 virus infection in critically ill patients and impact on clinical outcome.
Auteurs : Francisco Álvarez-Lerma [Espagne] ; Judith Marín-Corral [Espagne] ; Clara Vila [Espagne] ; Joan Ram N Masclans [Espagne] ; Francisco Javier González De Molina [Espagne] ; Ignacio Martín Loeches [Irlande (pays)] ; Sandra Barbadillo [Espagne] ; Alejandro Rodríguez [Espagne]Source :
- Critical care (London, England) [ 1466-609X ] ; 2016.
Descripteurs français
- KwdFr :
- Adulte (MeSH), Adulte d'âge moyen (MeSH), Durée du séjour (MeSH), Espagne (épidémiologie), Facteurs de risque (MeSH), Femelle (MeSH), Grippe humaine (diagnostic), Humains (MeSH), Loi du khi-deux (MeSH), Maladie grave (épidémiologie), Modèles logistiques (MeSH), Mortalité hospitalière (MeSH), Mâle (MeSH), Odds ratio (MeSH), Retard de diagnostic (MeSH), Sous-type H1N1 du virus de la grippe A (pathogénicité), Statistique non paramétrique (MeSH), Sujet âgé (MeSH), Unités de soins intensifs (organisation et administration), Unités de soins intensifs (statistiques et données numériques), Études prospectives (MeSH).
- MESH :
- diagnostic : Grippe humaine.
- organisation et administration : Unités de soins intensifs.
- pathogénicité : Sous-type H1N1 du virus de la grippe A.
- statistiques et données numériques : Unités de soins intensifs.
- épidémiologie : Espagne, Maladie grave.
- Adulte, Adulte d'âge moyen, Durée du séjour, Facteurs de risque, Femelle, Humains, Loi du khi-deux, Modèles logistiques, Mortalité hospitalière, Mâle, Odds ratio, Retard de diagnostic, Statistique non paramétrique, Sujet âgé, Études prospectives.
English descriptors
- KwdEn :
- Adult (MeSH), Aged (MeSH), Chi-Square Distribution (MeSH), Critical Illness (epidemiology), Delayed Diagnosis (MeSH), Female (MeSH), Hospital Mortality (MeSH), Humans (MeSH), Influenza A Virus, H1N1 Subtype (pathogenicity), Influenza, Human (diagnosis), Intensive Care Units (organization & administration), Intensive Care Units (statistics & numerical data), Length of Stay (MeSH), Logistic Models (MeSH), Male (MeSH), Middle Aged (MeSH), Odds Ratio (MeSH), Prospective Studies (MeSH), Risk Factors (MeSH), Spain (epidemiology), Statistics, Nonparametric (MeSH).
- MESH :
- diagnosis : Influenza, Human.
- epidemiology : Critical Illness, Spain.
- organization & administration : Intensive Care Units.
- pathogenicity : Influenza A Virus, H1N1 Subtype.
- statistics & numerical data : Intensive Care Units.
- Adult, Aged, Chi-Square Distribution, Delayed Diagnosis, Female, Hospital Mortality, Humans, Length of Stay, Logistic Models, Male, Middle Aged, Odds Ratio, Prospective Studies, Risk Factors, Statistics, Nonparametric.
Abstract
BACKGROUND
Patients infected with influenza A (H1N1)pdm09 virus requiring admission to the ICU remain an important source of mortality during the influenza season. The objective of the study was to assess the impact of a delay in diagnosis of community-acquired influenza A (H1N1)pdm09 virus infection on clinical outcome in critically ill patients admitted to the ICU.
METHODS
A prospective multicenter observational cohort study was based on data from the GETGAG/SEMICYUC registry (2009-2015) collected by 148 Spanish ICUs. All patients admitted to the ICU in which diagnosis of influenza A (H1N1)pdm09 virus infection had been established within the first week of hospitalization were included. Patients were classified into two groups according to the time at which the diagnosis was made: early (within the first 2 days of hospital admission) and late (between the 3rd and 7th day of hospital admission). Factors associated with a delay in diagnosis were assessed by logistic regression analysis.
RESULTS
In 2059 ICU patients diagnosed with influenza A (H1N1)pdm09 virus infection within the first 7 days of hospitalization, the diagnosis was established early in 1314 (63.8 %) patients and late in the remaining 745 (36.2 %). Independent variables related to a late diagnosis were: age (odds ratio (OR) = 1.02, 95 % confidence interval (CI) 1.01-1.03, P < 0.001); first seasonal period (2009-2012) (OR = 2.08, 95 % CI 1.64-2.63, P < 0.001); days of hospital stay before ICU admission (OR = 1.26, 95 % CI 1.17-1.35, P < 0.001); mechanical ventilation (OR = 1.58, 95 % CI 1.17-2.13, P = 0.002); and continuous venovenous hemofiltration (OR = 1.54, 95 % CI 1.08-2.18, P = 0.016). The intra-ICU mortality was significantly higher among patients with late diagnosis as compared with early diagnosis (26.9 % vs 17.1 %, P < 0.001). Diagnostic delay was one independent risk factor for mortality (OR = 1.36, 95 % CI 1.03-1.81, P < 0.001).
CONCLUSIONS
Late diagnosis of community-acquired influenza A (H1N1)pdm09 virus infection is associated with a delay in ICU admission, greater possibilities of respiratory and renal failure, and higher mortality rate. Delay in diagnosis of flu is an independent variable related to death.
DOI: 10.1186/s13054-016-1512-1
PubMed: 27770828
PubMed Central: PMC5075413
Affiliations:
- Espagne, Irlande (pays)
- Catalogne, Communauté de Madrid
- Barcelone, Madrid
- Université Pompeu Fabra, Université autonome de Barcelone
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Delay in diagnosis of influenza A (H1N1)pdm09 virus infection in critically ill patients and impact on clinical outcome.</title><author><name sortKey="Alvarez Lerma, Francisco" sort="Alvarez Lerma, Francisco" uniqKey="Alvarez Lerma F" first="Francisco" last="Álvarez-Lerma">Francisco Álvarez-Lerma</name><affiliation wicri:level="3"><nlm:affiliation>Service of Intensive Care Medicine, Hospital del Mar, Passeig Marítim 25-29, E-08003, Barcelona, Spain. FAlvarez@parcdesalutmar.cat.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Service of Intensive Care Medicine, Hospital del Mar, Passeig Marítim 25-29, E-08003, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Research Group in Critical Disorders (GREPAC), Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona, Spain. FAlvarez@parcdesalutmar.cat.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Research Group in Critical Disorders (GREPAC), Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Universitat Autónoma de Barcelona, Barcelona, Spain. FAlvarez@parcdesalutmar.cat.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Universitat Autónoma de Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName><orgName type="university">Université autonome de Barcelone</orgName></affiliation></author><author><name sortKey="Marin Corral, Judith" sort="Marin Corral, Judith" uniqKey="Marin Corral J" first="Judith" last="Marín-Corral">Judith Marín-Corral</name><affiliation wicri:level="3"><nlm:affiliation>Service of Intensive Care Medicine, Hospital del Mar, Passeig Marítim 25-29, E-08003, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Service of Intensive Care Medicine, Hospital del Mar, Passeig Marítim 25-29, E-08003, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Research Group in Critical Disorders (GREPAC), Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Research Group in Critical Disorders (GREPAC), Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Vila, Clara" sort="Vila, Clara" uniqKey="Vila C" first="Clara" last="Vila">Clara Vila</name><affiliation wicri:level="3"><nlm:affiliation>Service of Intensive Care Medicine, Hospital del Mar, Passeig Marítim 25-29, E-08003, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Service of Intensive Care Medicine, Hospital del Mar, Passeig Marítim 25-29, E-08003, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Masclans, Joan Ram N" sort="Masclans, Joan Ram N" uniqKey="Masclans J" first="Joan Ram N" last="Masclans">Joan Ram N Masclans</name><affiliation wicri:level="3"><nlm:affiliation>Service of Intensive Care Medicine, Hospital del Mar, Passeig Marítim 25-29, E-08003, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Service of Intensive Care Medicine, Hospital del Mar, Passeig Marítim 25-29, E-08003, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Research Group in Critical Disorders (GREPAC), Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Research Group in Critical Disorders (GREPAC), Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>CIBER de Enfermedades Respiratorias (CIBERES), Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER de Enfermedades Respiratorias (CIBERES), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Universitat Pompeu Fabra, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Universitat Pompeu Fabra, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName><orgName type="university">Université Pompeu Fabra</orgName></affiliation></author><author><name sortKey="Gonzalez De Molina, Francisco Javier" sort="Gonzalez De Molina, Francisco Javier" uniqKey="Gonzalez De Molina F" first="Francisco Javier" last="González De Molina">Francisco Javier González De Molina</name><affiliation wicri:level="3"><nlm:affiliation>Service of Intensive Care Medicine, Hospital Universitari Mútua de Terrassa, Terrassa, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Service of Intensive Care Medicine, Hospital Universitari Mútua de Terrassa, Terrassa, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Martin Loeches, Ignacio" sort="Martin Loeches, Ignacio" uniqKey="Martin Loeches I" first="Ignacio" last="Martín Loeches">Ignacio Martín Loeches</name><affiliation wicri:level="1"><nlm:affiliation>Service of Intensive Care Medicine, St James Hospital, Dublin, Ireland.</nlm:affiliation><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Service of Intensive Care Medicine, St James Hospital, Dublin</wicri:regionArea><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Barbadillo, Sandra" sort="Barbadillo, Sandra" uniqKey="Barbadillo S" first="Sandra" last="Barbadillo">Sandra Barbadillo</name><affiliation wicri:level="3"><nlm:affiliation>Service of Intensive Care Medicine, Hospital General de Catalunya, Sant Cugat del Vallés, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Service of Intensive Care Medicine, Hospital General de Catalunya, Sant Cugat del Vallés, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Rodriguez, Alejandro" sort="Rodriguez, Alejandro" uniqKey="Rodriguez A" first="Alejandro" last="Rodríguez">Alejandro Rodríguez</name><affiliation wicri:level="3"><nlm:affiliation>CIBER de Enfermedades Respiratorias (CIBERES), Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER de Enfermedades Respiratorias (CIBERES), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Service of Intensive Care Medicine, Hospital Universitari Joan XXIII, IISPV-URV, Tarragona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Service of Intensive Care Medicine, Hospital Universitari Joan XXIII, IISPV-URV, Tarragona</wicri:regionArea><wicri:noRegion>Tarragona</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27770828</idno><idno type="pmid">27770828</idno><idno type="doi">10.1186/s13054-016-1512-1</idno><idno type="pmc">PMC5075413</idno><idno type="wicri:Area/Main/Corpus">00111</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">00111</idno><idno type="wicri:Area/Main/Curation">000111</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000111</idno><idno type="wicri:Area/Main/Exploration">000111</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Delay in diagnosis of influenza A (H1N1)pdm09 virus infection in critically ill patients and impact on clinical outcome.</title><author><name sortKey="Alvarez Lerma, Francisco" sort="Alvarez Lerma, Francisco" uniqKey="Alvarez Lerma F" first="Francisco" last="Álvarez-Lerma">Francisco Álvarez-Lerma</name><affiliation wicri:level="3"><nlm:affiliation>Service of Intensive Care Medicine, Hospital del Mar, Passeig Marítim 25-29, E-08003, Barcelona, Spain. FAlvarez@parcdesalutmar.cat.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Service of Intensive Care Medicine, Hospital del Mar, Passeig Marítim 25-29, E-08003, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Research Group in Critical Disorders (GREPAC), Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona, Spain. FAlvarez@parcdesalutmar.cat.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Research Group in Critical Disorders (GREPAC), Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Universitat Autónoma de Barcelona, Barcelona, Spain. FAlvarez@parcdesalutmar.cat.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Universitat Autónoma de Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName><orgName type="university">Université autonome de Barcelone</orgName></affiliation></author><author><name sortKey="Marin Corral, Judith" sort="Marin Corral, Judith" uniqKey="Marin Corral J" first="Judith" last="Marín-Corral">Judith Marín-Corral</name><affiliation wicri:level="3"><nlm:affiliation>Service of Intensive Care Medicine, Hospital del Mar, Passeig Marítim 25-29, E-08003, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Service of Intensive Care Medicine, Hospital del Mar, Passeig Marítim 25-29, E-08003, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Research Group in Critical Disorders (GREPAC), Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Research Group in Critical Disorders (GREPAC), Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Vila, Clara" sort="Vila, Clara" uniqKey="Vila C" first="Clara" last="Vila">Clara Vila</name><affiliation wicri:level="3"><nlm:affiliation>Service of Intensive Care Medicine, Hospital del Mar, Passeig Marítim 25-29, E-08003, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Service of Intensive Care Medicine, Hospital del Mar, Passeig Marítim 25-29, E-08003, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Masclans, Joan Ram N" sort="Masclans, Joan Ram N" uniqKey="Masclans J" first="Joan Ram N" last="Masclans">Joan Ram N Masclans</name><affiliation wicri:level="3"><nlm:affiliation>Service of Intensive Care Medicine, Hospital del Mar, Passeig Marítim 25-29, E-08003, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Service of Intensive Care Medicine, Hospital del Mar, Passeig Marítim 25-29, E-08003, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Research Group in Critical Disorders (GREPAC), Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Research Group in Critical Disorders (GREPAC), Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>CIBER de Enfermedades Respiratorias (CIBERES), Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER de Enfermedades Respiratorias (CIBERES), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="4"><nlm:affiliation>Universitat Pompeu Fabra, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Universitat Pompeu Fabra, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName><orgName type="university">Université Pompeu Fabra</orgName></affiliation></author><author><name sortKey="Gonzalez De Molina, Francisco Javier" sort="Gonzalez De Molina, Francisco Javier" uniqKey="Gonzalez De Molina F" first="Francisco Javier" last="González De Molina">Francisco Javier González De Molina</name><affiliation wicri:level="3"><nlm:affiliation>Service of Intensive Care Medicine, Hospital Universitari Mútua de Terrassa, Terrassa, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Service of Intensive Care Medicine, Hospital Universitari Mútua de Terrassa, Terrassa, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Martin Loeches, Ignacio" sort="Martin Loeches, Ignacio" uniqKey="Martin Loeches I" first="Ignacio" last="Martín Loeches">Ignacio Martín Loeches</name><affiliation wicri:level="1"><nlm:affiliation>Service of Intensive Care Medicine, St James Hospital, Dublin, Ireland.</nlm:affiliation><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Service of Intensive Care Medicine, St James Hospital, Dublin</wicri:regionArea><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Barbadillo, Sandra" sort="Barbadillo, Sandra" uniqKey="Barbadillo S" first="Sandra" last="Barbadillo">Sandra Barbadillo</name><affiliation wicri:level="3"><nlm:affiliation>Service of Intensive Care Medicine, Hospital General de Catalunya, Sant Cugat del Vallés, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Service of Intensive Care Medicine, Hospital General de Catalunya, Sant Cugat del Vallés, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Rodriguez, Alejandro" sort="Rodriguez, Alejandro" uniqKey="Rodriguez A" first="Alejandro" last="Rodríguez">Alejandro Rodríguez</name><affiliation wicri:level="3"><nlm:affiliation>CIBER de Enfermedades Respiratorias (CIBERES), Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>CIBER de Enfermedades Respiratorias (CIBERES), Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Service of Intensive Care Medicine, Hospital Universitari Joan XXIII, IISPV-URV, Tarragona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Service of Intensive Care Medicine, Hospital Universitari Joan XXIII, IISPV-URV, Tarragona</wicri:regionArea><wicri:noRegion>Tarragona</wicri:noRegion></affiliation></author></analytic><series><title level="j">Critical care (London, England)</title><idno type="eISSN">1466-609X</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>Aged (MeSH)</term><term>Chi-Square Distribution (MeSH)</term><term>Critical Illness (epidemiology)</term><term>Delayed Diagnosis (MeSH)</term><term>Female (MeSH)</term><term>Hospital Mortality (MeSH)</term><term>Humans (MeSH)</term><term>Influenza A Virus, H1N1 Subtype (pathogenicity)</term><term>Influenza, Human (diagnosis)</term><term>Intensive Care Units (organization & administration)</term><term>Intensive Care Units (statistics & numerical data)</term><term>Length of Stay (MeSH)</term><term>Logistic Models (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Odds Ratio (MeSH)</term><term>Prospective Studies (MeSH)</term><term>Risk Factors (MeSH)</term><term>Spain (epidemiology)</term><term>Statistics, Nonparametric (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Durée du séjour (MeSH)</term><term>Espagne (épidémiologie)</term><term>Facteurs de risque (MeSH)</term><term>Femelle (MeSH)</term><term>Grippe humaine (diagnostic)</term><term>Humains (MeSH)</term><term>Loi du khi-deux (MeSH)</term><term>Maladie grave (épidémiologie)</term><term>Modèles logistiques (MeSH)</term><term>Mortalité hospitalière (MeSH)</term><term>Mâle (MeSH)</term><term>Odds ratio (MeSH)</term><term>Retard de diagnostic (MeSH)</term><term>Sous-type H1N1 du virus de la grippe A (pathogénicité)</term><term>Statistique non paramétrique (MeSH)</term><term>Sujet âgé (MeSH)</term><term>Unités de soins intensifs (organisation et administration)</term><term>Unités de soins intensifs (statistiques et données numériques)</term><term>Études prospectives (MeSH)</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Critical Illness</term><term>Spain</term></keywords><keywords scheme="MESH" qualifier="organisation et administration" xml:lang="fr"><term>Unités de soins intensifs</term></keywords><keywords scheme="MESH" qualifier="organization & administration" xml:lang="en"><term>Intensive Care Units</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Sous-type H1N1 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Intensive Care Units</term></keywords><keywords scheme="MESH" qualifier="statistiques et données numériques" xml:lang="fr"><term>Unités de soins intensifs</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Espagne</term><term>Maladie grave</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Chi-Square Distribution</term><term>Delayed Diagnosis</term><term>Female</term><term>Hospital Mortality</term><term>Humans</term><term>Length of Stay</term><term>Logistic Models</term><term>Male</term><term>Middle Aged</term><term>Odds Ratio</term><term>Prospective Studies</term><term>Risk Factors</term><term>Statistics, Nonparametric</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Durée du séjour</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Loi du khi-deux</term><term>Modèles logistiques</term><term>Mortalité hospitalière</term><term>Mâle</term><term>Odds ratio</term><term>Retard de diagnostic</term><term>Statistique non paramétrique</term><term>Sujet âgé</term><term>Études prospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Patients infected with influenza A (H1N1)pdm09 virus requiring admission to the ICU remain an important source of mortality during the influenza season. The objective of the study was to assess the impact of a delay in diagnosis of community-acquired influenza A (H1N1)pdm09 virus infection on clinical outcome in critically ill patients admitted to the ICU.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>A prospective multicenter observational cohort study was based on data from the GETGAG/SEMICYUC registry (2009-2015) collected by 148 Spanish ICUs. All patients admitted to the ICU in which diagnosis of influenza A (H1N1)pdm09 virus infection had been established within the first week of hospitalization were included. Patients were classified into two groups according to the time at which the diagnosis was made: early (within the first 2 days of hospital admission) and late (between the 3rd and 7th day of hospital admission). Factors associated with a delay in diagnosis were assessed by logistic regression analysis.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>In 2059 ICU patients diagnosed with influenza A (H1N1)pdm09 virus infection within the first 7 days of hospitalization, the diagnosis was established early in 1314 (63.8 %) patients and late in the remaining 745 (36.2 %). Independent variables related to a late diagnosis were: age (odds ratio (OR) = 1.02, 95 % confidence interval (CI) 1.01-1.03, P < 0.001); first seasonal period (2009-2012) (OR = 2.08, 95 % CI 1.64-2.63, P < 0.001); days of hospital stay before ICU admission (OR = 1.26, 95 % CI 1.17-1.35, P < 0.001); mechanical ventilation (OR = 1.58, 95 % CI 1.17-2.13, P = 0.002); and continuous venovenous hemofiltration (OR = 1.54, 95 % CI 1.08-2.18, P = 0.016). The intra-ICU mortality was significantly higher among patients with late diagnosis as compared with early diagnosis (26.9 % vs 17.1 %, P < 0.001). Diagnostic delay was one independent risk factor for mortality (OR = 1.36, 95 % CI 1.03-1.81, P < 0.001).</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>Late diagnosis of community-acquired influenza A (H1N1)pdm09 virus infection is associated with a delay in ICU admission, greater possibilities of respiratory and renal failure, and higher mortality rate. Delay in diagnosis of flu is an independent variable related to death.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27770828</PMID><DateCompleted><Year>2018</Year><Month>03</Month><Day>06</Day></DateCompleted><DateRevised><Year>2018</Year><Month>11</Month><Day>13</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1466-609X</ISSN><JournalIssue CitedMedium="Internet"><Volume>20</Volume><Issue>1</Issue><PubDate><Year>2016</Year><Month>Oct</Month><Day>23</Day></PubDate></JournalIssue><Title>Critical care (London, England)</Title><ISOAbbreviation>Crit Care</ISOAbbreviation></Journal><ArticleTitle>Delay in diagnosis of influenza A (H1N1)pdm09 virus infection in critically ill patients and impact on clinical outcome.</ArticleTitle><Pagination><MedlinePgn>337</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Patients infected with influenza A (H1N1)pdm09 virus requiring admission to the ICU remain an important source of mortality during the influenza season. The objective of the study was to assess the impact of a delay in diagnosis of community-acquired influenza A (H1N1)pdm09 virus infection on clinical outcome in critically ill patients admitted to the ICU.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">A prospective multicenter observational cohort study was based on data from the GETGAG/SEMICYUC registry (2009-2015) collected by 148 Spanish ICUs. All patients admitted to the ICU in which diagnosis of influenza A (H1N1)pdm09 virus infection had been established within the first week of hospitalization were included. Patients were classified into two groups according to the time at which the diagnosis was made: early (within the first 2 days of hospital admission) and late (between the 3rd and 7th day of hospital admission). Factors associated with a delay in diagnosis were assessed by logistic regression analysis.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">In 2059 ICU patients diagnosed with influenza A (H1N1)pdm09 virus infection within the first 7 days of hospitalization, the diagnosis was established early in 1314 (63.8 %) patients and late in the remaining 745 (36.2 %). Independent variables related to a late diagnosis were: age (odds ratio (OR) = 1.02, 95 % confidence interval (CI) 1.01-1.03, P < 0.001); first seasonal period (2009-2012) (OR = 2.08, 95 % CI 1.64-2.63, P < 0.001); days of hospital stay before ICU admission (OR = 1.26, 95 % CI 1.17-1.35, P < 0.001); mechanical ventilation (OR = 1.58, 95 % CI 1.17-2.13, P = 0.002); and continuous venovenous hemofiltration (OR = 1.54, 95 % CI 1.08-2.18, P = 0.016). The intra-ICU mortality was significantly higher among patients with late diagnosis as compared with early diagnosis (26.9 % vs 17.1 %, P < 0.001). Diagnostic delay was one independent risk factor for mortality (OR = 1.36, 95 % CI 1.03-1.81, P < 0.001).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Late diagnosis of community-acquired influenza A (H1N1)pdm09 virus infection is associated with a delay in ICU admission, greater possibilities of respiratory and renal failure, and higher mortality rate. Delay in diagnosis of flu is an independent variable related to death.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Álvarez-Lerma</LastName><ForeName>Francisco</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Service of Intensive Care Medicine, Hospital del Mar, Passeig Marítim 25-29, E-08003, Barcelona, Spain. FAlvarez@parcdesalutmar.cat.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Research Group in Critical Disorders (GREPAC), Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona, Spain. FAlvarez@parcdesalutmar.cat.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Universitat Autónoma de Barcelona, Barcelona, Spain. FAlvarez@parcdesalutmar.cat.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marín-Corral</LastName><ForeName>Judith</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Service of Intensive Care Medicine, Hospital del Mar, Passeig Marítim 25-29, E-08003, Barcelona, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Research Group in Critical Disorders (GREPAC), Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vila</LastName><ForeName>Clara</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Service of Intensive Care Medicine, Hospital del Mar, Passeig Marítim 25-29, E-08003, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Masclans</LastName><ForeName>Joan Ramón</ForeName><Initials>JR</Initials><AffiliationInfo><Affiliation>Service of Intensive Care Medicine, Hospital del Mar, Passeig Marítim 25-29, E-08003, Barcelona, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Research Group in Critical Disorders (GREPAC), Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>CIBER de Enfermedades Respiratorias (CIBERES), Madrid, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Universitat Pompeu Fabra, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>González de Molina</LastName><ForeName>Francisco Javier</ForeName><Initials>FJ</Initials><AffiliationInfo><Affiliation>Service of Intensive Care Medicine, Hospital Universitari Mútua de Terrassa, Terrassa, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martín Loeches</LastName><ForeName>Ignacio</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Service of Intensive Care Medicine, St James Hospital, Dublin, Ireland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Barbadillo</LastName><ForeName>Sandra</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Service of Intensive Care Medicine, Hospital General de Catalunya, Sant Cugat del Vallés, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rodríguez</LastName><ForeName>Alejandro</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>CIBER de Enfermedades Respiratorias (CIBERES), Madrid, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Service of Intensive Care Medicine, Hospital Universitari Joan XXIII, IISPV-URV, Tarragona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>H1N1 GETGAG/SEMICYUC Study Group</CollectiveName></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>10</Month><Day>23</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Crit Care</MedlineTA><NlmUniqueID>9801902</NlmUniqueID><ISSNLinking>1364-8535</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016009" MajorTopicYN="N">Chi-Square Distribution</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016638" MajorTopicYN="N">Critical Illness</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D057210" MajorTopicYN="N">Delayed Diagnosis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017052" MajorTopicYN="N">Hospital Mortality</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053118" MajorTopicYN="N">Influenza A Virus, H1N1 Subtype</DescriptorName><QualifierName UI="Q000472" MajorTopicYN="N">pathogenicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007362" MajorTopicYN="N">Intensive Care Units</DescriptorName><QualifierName UI="Q000458" MajorTopicYN="N">organization & administration</QualifierName><QualifierName UI="Q000706" MajorTopicYN="N">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007902" MajorTopicYN="N">Length of Stay</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016015" MajorTopicYN="N">Logistic Models</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016017" MajorTopicYN="N">Odds Ratio</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013030" MajorTopicYN="N">Spain</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018709" MajorTopicYN="N">Statistics, Nonparametric</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Critically ill</Keyword><Keyword MajorTopicYN="N">Early diagnosis</Keyword><Keyword MajorTopicYN="N">ICU</Keyword><Keyword MajorTopicYN="N">Influenza A (H1N1)pdm09 virus infection</Keyword><Keyword MajorTopicYN="N">Late diagnosis</Keyword><Keyword MajorTopicYN="N">Mortality</Keyword><Keyword MajorTopicYN="N">Outcome</Keyword></KeywordList><InvestigatorList><Investigator ValidYN="Y"><LastName>Cobo</LastName><ForeName>Pedro</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Martins</LastName><ForeName>Javier</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Carbayo</LastName><ForeName>Cecilia</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Robles-Musso</LastName><ForeName>Emilio</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Cárdenas</LastName><ForeName>Antonio</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Fierro</LastName><ForeName>Javier</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Fernández</LastName><ForeName>Dolores Ocaña</ForeName><Initials>DO</Initials></Investigator><Investigator ValidYN="Y"><LastName>Sierra</LastName><ForeName>Rafael</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Huertos</LastName><ForeName>Ma Jesús</ForeName><Initials>MJ</Initials></Investigator><Investigator ValidYN="Y"><LastName>Pérez</LastName><ForeName>Ma Luz Carmona</ForeName><Initials>ML</Initials></Investigator><Investigator ValidYN="Y"><LastName>Laderas</LastName><ForeName>Juan Carlos Pozo</ForeName><Initials>JC</Initials></Investigator><Investigator ValidYN="Y"><LastName>Guerrero</LastName><ForeName>R</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Robles</LastName><ForeName>Juan Carlos</ForeName><Initials>JC</Initials></Investigator><Investigator ValidYN="Y"><LastName>León</LastName><ForeName>Melissa Echevarría</ForeName><Initials>ME</Initials></Investigator><Investigator ValidYN="Y"><LastName>Gómez</LastName><ForeName>Alberto Bermejo</ForeName><Initials>AB</Initials></Investigator><Investigator ValidYN="Y"><LastName>Márquez</LastName><ForeName>Enrique</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Rodríguez-Carvajal</LastName><ForeName>Manuel</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Estella</LastName><ForeName>Ángel</ForeName><Initials>Á</Initials></Investigator><Investigator ValidYN="Y"><LastName>Pomares</LastName><ForeName>José</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ballesteros</LastName><ForeName>José Luis</ForeName><Initials>JL</Initials></Investigator><Investigator ValidYN="Y"><LastName>Romero</LastName><ForeName>Olga Moreno</ForeName><Initials>OM</Initials></Investigator><Investigator ValidYN="Y"><LastName>Fernández</LastName><ForeName>Yolanda</ForeName><Initials>Y</Initials></Investigator><Investigator ValidYN="Y"><LastName>Lobato</LastName><ForeName>Francisco</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>Prieto</LastName><ForeName>José F</ForeName><Initials>JF</Initials></Investigator><Investigator ValidYN="Y"><LastName>Albofedo-Sánchez</LastName><ForeName>José</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Martínez</LastName><ForeName>Pilar</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>de la Torre</LastName><ForeName>María Victoria</ForeName><Initials>MV</Initials></Investigator><Investigator ValidYN="Y"><LastName>Nieto</LastName><ForeName>María</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Sola</LastName><ForeName>Estefanía Cámara</ForeName><Initials>EC</Initials></Investigator><Investigator ValidYN="Y"><LastName>Castellanos</LastName><ForeName>Miguel Ángel Díaz</ForeName><Initials>MÁ</Initials></Investigator><Investigator ValidYN="Y"><LastName>Soler</LastName><ForeName>Guillermo Sevilla</ForeName><Initials>GS</Initials></Investigator><Investigator ValidYN="Y"><LastName>Leyba</LastName><ForeName>Carlos Ortiz</ForeName><Initials>CO</Initials></Investigator><Investigator ValidYN="Y"><LastName>Garnacho-Montero</LastName><ForeName>José</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Hinojosa</LastName><ForeName>Rafael</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Fernández</LastName><ForeName>Esteban</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Loza</LastName><ForeName>Ana</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>León</LastName><ForeName>Cristóbal</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>López</LastName><ForeName>Samuel González</ForeName><Initials>SG</Initials></Investigator><Investigator ValidYN="Y"><LastName>Arenzana</LastName><ForeName>Ángel</ForeName><Initials>Á</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ocaña</LastName><ForeName>Dolores</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Navarrete</LastName><ForeName>Inés</ForeName><Initials>I</Initials></Investigator><Investigator ValidYN="Y"><LastName>Beryanaki</LastName><ForeName>Medhi Zaheri</ForeName><Initials>MZ</Initials></Investigator><Investigator ValidYN="Y"><LastName>Sánchez</LastName><ForeName>Ignacio</ForeName><Initials>I</Initials></Investigator><Investigator ValidYN="Y"><LastName>Alé</LastName><ForeName>Manuel Pérez</ForeName><Initials>MP</Initials></Investigator><Investigator ValidYN="Y"><LastName>Brea</LastName><ForeName>Ana Ma Poullet</ForeName><Initials>AM</Initials></Investigator><Investigator ValidYN="Y"><LastName>Casas</LastName><ForeName>Juan Francisco Machado</ForeName><Initials>JF</Initials></Investigator><Investigator ValidYN="Y"><LastName>Serón</LastName><ForeName>Carlos</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Avellanas</LastName><ForeName>Manuel Luis</ForeName><Initials>ML</Initials></Investigator><Investigator ValidYN="Y"><LastName>Lander</LastName><ForeName>Arantxa</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>de Arellano</LastName><ForeName>S Garrido Ramírez</ForeName><Initials>SG</Initials></Investigator><Investigator ValidYN="Y"><LastName>Lacueva</LastName><ForeName>M I Marquina</ForeName><Initials>MI</Initials></Investigator><Investigator ValidYN="Y"><LastName>Luque</LastName><ForeName>Pilar</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Serrano</LastName><ForeName>Elena Plumed</ForeName><Initials>EP</Initials></Investigator><Investigator ValidYN="Y"><LastName>Lázaro</LastName><ForeName>Juan Francisco Martín</ForeName><Initials>JF</Initials></Investigator><Investigator ValidYN="Y"><LastName>Polo</LastName><ForeName>Carlos Sánchez</ForeName><Initials>CS</Initials></Investigator><Investigator ValidYN="Y"><LastName>Cía</LastName><ForeName>Isabel Gutiérrez</ForeName><Initials>IG</Initials></Investigator><Investigator ValidYN="Y"><LastName>Bartolomé</LastName><ForeName>Belén Jiménez</ForeName><Initials>BJ</Initials></Investigator><Investigator ValidYN="Y"><LastName>Núñez</LastName><ForeName>Carlos López</ForeName><Initials>CL</Initials></Investigator><Investigator ValidYN="Y"><LastName>González</LastName><ForeName>Ignacio</ForeName><Initials>I</Initials></Investigator><Investigator ValidYN="Y"><LastName>Marsilla</LastName><ForeName>José Ignacio Tomás</ForeName><Initials>JI</Initials></Investigator><Investigator ValidYN="Y"><LastName>Andrés</LastName><ForeName>Clara Jaques</ForeName><Initials>CJ</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ibañes</LastName><ForeName>Pablo Gutiérrez</ForeName><Initials>PG</Initials></Investigator><Investigator ValidYN="Y"><LastName>Aguilar</LastName><ForeName>Pilar Araujo</ForeName><Initials>PA</Initials></Investigator><Investigator ValidYN="Y"><LastName>Montón</LastName><ForeName>Jose Ma</ForeName><Initials>JM</Initials></Investigator><Investigator ValidYN="Y"><LastName>Regil</LastName><ForeName>Paloma Dorado</ForeName><Initials>PD</Initials></Investigator><Investigator ValidYN="Y"><LastName>Iglesias</LastName><ForeName>Lisardo</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>González</LastName><ForeName>Carmen Pascual</ForeName><Initials>CP</Initials></Investigator><Investigator ValidYN="Y"><LastName>Fernández</LastName><ForeName>Brígida Quindós</ForeName><Initials>BQ</Initials></Investigator><Investigator ValidYN="Y"><LastName>Iglesias</LastName><ForeName>Lorena Martín</ForeName><Initials>LM</Initials></Investigator><Investigator ValidYN="Y"><LastName>Soria</LastName><ForeName>Lucía Viña</ForeName><Initials>LV</Initials></Investigator><Investigator ValidYN="Y"><LastName>Escudero</LastName><ForeName>Raquel Yano</ForeName><Initials>RY</Initials></Investigator><Investigator ValidYN="Y"><LastName>Revuelta</LastName><ForeName>Ma Del Rosario Martínez</ForeName><Initials>MD</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ruiz</LastName><ForeName>José Ma Quiroga</ForeName><Initials>JM</Initials></Investigator><Investigator ValidYN="Y"><LastName>García-Rodríguez</LastName><ForeName>Águeda</ForeName><Initials>Á</Initials></Investigator><Investigator ValidYN="Y"><LastName>Cuadrado</LastName><ForeName>Marta Martín</ForeName><Initials>MM</Initials></Investigator><Investigator ValidYN="Y"><LastName>Mariño</LastName><ForeName>Ana Luz Balán</ForeName><Initials>AL</Initials></Investigator><Investigator ValidYN="Y"><LastName>Socias</LastName><ForeName>Lorenzo</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ibáñez</LastName><ForeName>Pedro</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Borges-Sa</LastName><ForeName>Marcío</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Socias</LastName><ForeName>A</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Del Castillo</LastName><ForeName>A</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Marcos</LastName><ForeName>Ricard Jordà</ForeName><Initials>RJ</Initials></Investigator><Investigator ValidYN="Y"><LastName>Muñoz</LastName><ForeName>Cristina</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Goytisolo</LastName><ForeName>José M Bonell</ForeName><Initials>JM</Initials></Investigator><Investigator ValidYN="Y"><LastName>Carbonero</LastName><ForeName>José Antonio Morales</ForeName><Initials>JA</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ayestarán</LastName><ForeName>Ignacio</ForeName><Initials>I</Initials></Investigator><Investigator ValidYN="Y"><LastName>López</LastName><ForeName>M Ángeles González</ForeName><Initials>MÁ</Initials></Investigator><Investigator ValidYN="Y"><LastName>Pàmies</LastName><ForeName>Cecilia Vilanova</ForeName><Initials>CV</Initials></Investigator><Investigator ValidYN="Y"><LastName>Senoff</LastName><ForeName>Rossana Pérez</ForeName><Initials>RP</Initials></Investigator><Investigator ValidYN="Y"><LastName>de Medrano</LastName><ForeName>Marta Generelo López</ForeName><Initials>MG</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ruiz-Santana</LastName><ForeName>Sergio</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Díaz</LastName><ForeName>Juan José</ForeName><Initials>JJ</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ramírez</LastName><ForeName>Catalina Sánchez</ForeName><Initials>CS</Initials></Investigator><Investigator ValidYN="Y"><LastName>Sisón</LastName><ForeName>Montse</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Hernández</LastName><ForeName>David</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Trujillo</LastName><ForeName>Ana</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Regalado</LastName><ForeName>Luis</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Fernández</LastName><ForeName>Sonia Rodríguez</ForeName><Initials>SR</Initials></Investigator><Investigator ValidYN="Y"><LastName>Lorente</LastName><ForeName>Leonardo</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Rivero</LastName><ForeName>Judith Cabrera</ForeName><Initials>JC</Initials></Investigator><Investigator ValidYN="Y"><LastName>Quintero</LastName><ForeName>Ma Luisa Mora</ForeName><Initials>ML</Initials></Investigator><Investigator ValidYN="Y"><LastName>Martín</LastName><ForeName>Mar</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Martínez</LastName><ForeName>Sergio</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Cáceres</LastName><ForeName>J J</ForeName><Initials>JJ</Initials></Investigator><Investigator ValidYN="Y"><LastName>Palacio</LastName><ForeName>Manuel Sánchez</ForeName><Initials>MS</Initials></Investigator><Investigator ValidYN="Y"><LastName>Rodríguez</LastName><ForeName>D García</ForeName><Initials>DG</Initials></Investigator><Investigator ValidYN="Y"><LastName>Leria</LastName><ForeName>María Ripoll</ForeName><Initials>MR</Initials></Investigator><Investigator ValidYN="Y"><LastName>Suberviola</LastName><ForeName>Borja</ForeName><Initials>B</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ugarte</LastName><ForeName>P</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>García-López</LastName><ForeName>Fernando</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>Iniesta</LastName><ForeName>Rafael Sánchez</ForeName><Initials>RS</Initials></Investigator><Investigator ValidYN="Y"><LastName>Alonso</LastName><ForeName>Ángel Álvaro</ForeName><Initials>ÁÁ</Initials></Investigator><Investigator ValidYN="Y"><LastName>Padilla</LastName><ForeName>Antonio</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Palacios</LastName><ForeName>Basi Martínez</ForeName><Initials>BM</Initials></Investigator><Investigator ValidYN="Y"><LastName>Grande</LastName><ForeName>Ma Luisa Gómez</ForeName><Initials>ML</Initials></Investigator><Investigator ValidYN="Y"><LastName>Rodríguez</LastName><ForeName>Ma Carmen Martín</ForeName><Initials>MC</Initials></Investigator><Investigator ValidYN="Y"><LastName>Álvarez</LastName><ForeName>Hasania Adbel-Hadi</ForeName><Initials>HA</Initials></Investigator><Investigator ValidYN="Y"><LastName>Checa</LastName><ForeName>Alfonso Ambros</ForeName><Initials>AA</Initials></Investigator><Investigator ValidYN="Y"><LastName>Hernández</LastName><ForeName>Higinio Martín</ForeName><Initials>HM</Initials></Investigator><Investigator ValidYN="Y"><LastName>Albaya</LastName><ForeName>Antonio</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Obregón</LastName><ForeName>Alberto Silva</ForeName><Initials>AS</Initials></Investigator><Investigator ValidYN="Y"><LastName>Crespo</LastName><ForeName>Carlos Marian</ForeName><Initials>CM</Initials></Investigator><Investigator ValidYN="Y"><LastName>Estrella</LastName><ForeName>Carlos Armendáriz</ForeName><Initials>CA</Initials></Investigator><Investigator ValidYN="Y"><LastName>Puncel</LastName><ForeName>Carmen Benito</ForeName><Initials>CB</Initials></Investigator><Investigator ValidYN="Y"><LastName>Oyargue</LastName><ForeName>Eduardo Quirós</ForeName><Initials>EQ</Initials></Investigator><Investigator ValidYN="Y"><LastName>Canabal</LastName><ForeName>Alfonso</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Marina</LastName><ForeName>Luis</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>de Toro</LastName><ForeName>Ismael López</ForeName><Initials>IL</Initials></Investigator><Investigator ValidYN="Y"><LastName>Simón</LastName><ForeName>Almudena</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Añón</LastName><ForeName>José María</ForeName><Initials>JM</Initials></Investigator><Investigator ValidYN="Y"><LastName>Pueyo</LastName><ForeName>Ma Jesús López</ForeName><Initials>MJ</Initials></Investigator><Investigator ValidYN="Y"><LastName>Del Valle Ortiz</LastName><ForeName>María</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Echeverri</LastName><ForeName>Sergio Ossa</ForeName><Initials>SO</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ferreras</LastName><ForeName>Zulema</ForeName><Initials>Z</Initials></Investigator><Investigator ValidYN="Y"><LastName>Herraez</LastName><ForeName>Juan C Ballesteros</ForeName><Initials>JC</Initials></Investigator><Investigator ValidYN="Y"><LastName>Macías</LastName><ForeName>Santiago</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Berezo</LastName><ForeName>José Ángel</ForeName><Initials>JÁ</Initials></Investigator><Investigator ValidYN="Y"><LastName>Varela</LastName><ForeName>Jesús Blanco</ForeName><Initials>JB</Initials></Investigator><Investigator ValidYN="Y"><LastName>Schweizer</LastName><ForeName>Pablo Blanco</ForeName><Initials>PB</Initials></Investigator><Investigator ValidYN="Y"><LastName>Salamanca</LastName><ForeName>Ángela González</ForeName><Initials>ÁG</Initials></Investigator><Investigator ValidYN="Y"><LastName>Lomas</LastName><ForeName>Luis Tamayo</ForeName><Initials>LT</Initials></Investigator><Investigator ValidYN="Y"><LastName>Anzález</LastName><ForeName>Andaluz Ojeda</ForeName><Initials>AO</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ávila</LastName><ForeName>Ramón Cicuéndez</ForeName><Initials>RC</Initials></Investigator><Investigator ValidYN="Y"><LastName>Pérez</LastName><ForeName>G Francisco Javier</ForeName><Initials>GF</Initials></Investigator><Investigator ValidYN="Y"><LastName>Terrero</LastName><ForeName>Antonio Álvarez</ForeName><Initials>AÁ</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ezpeleta</LastName><ForeName>Fabiola Tena</ForeName><Initials>FT</Initials></Investigator><Investigator ValidYN="Y"><LastName>Sala</LastName><ForeName>Christian</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>López</LastName><ForeName>Oliverio</ForeName><Initials>O</Initials></Investigator><Investigator ValidYN="Y"><LastName>Páez</LastName><ForeName>Zulema</ForeName><Initials>Z</Initials></Investigator><Investigator ValidYN="Y"><LastName>García</LastName><ForeName>Álvaro</ForeName><Initials>Á</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ule</LastName><ForeName>Demetrio Carriedo</ForeName><Initials>DC</Initials></Investigator><Investigator ValidYN="Y"><LastName>Crespo</LastName><ForeName>Miriam Riesco</ForeName><Initials>MR</Initials></Investigator><Investigator ValidYN="Y"><LastName>Rebolledo</LastName><ForeName>Jesús Pino</ForeName><Initials>JP</Initials></Investigator><Investigator ValidYN="Y"><LastName>Andrés</LastName><ForeName>Nicolás Hidalgo</ForeName><Initials>NH</Initials></Investigator><Investigator ValidYN="Y"><LastName>Zirena</LastName><ForeName>Ana Carolina Caballero</ForeName><Initials>AC</Initials></Investigator><Investigator ValidYN="Y"><LastName>García</LastName><ForeName>Belén Román</ForeName><Initials>BR</Initials></Investigator><Investigator ValidYN="Y"><LastName>Messa</LastName><ForeName>Juan Bautista López</ForeName><Initials>JB</Initials></Investigator><Investigator ValidYN="Y"><LastName>Catalán</LastName><ForeName>Rosa Ma</ForeName><Initials>RM</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ferrer</LastName><ForeName>Miquel</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Torres</LastName><ForeName>Antoni</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Cilloniz</LastName><ForeName>Catia</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ansorregui</LastName><ForeName>Sandra Barbadillo</ForeName><Initials>SB</Initials></Investigator><Investigator ValidYN="Y"><LastName>Cabré</LastName><ForeName>Lluís</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Baeza</LastName><ForeName>Ignacio</ForeName><Initials>I</Initials></Investigator><Investigator ValidYN="Y"><LastName>Rovira</LastName><ForeName>Assumpta</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Álvarez-Lerma</LastName><ForeName>Francisco</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>Vázquez</LastName><ForeName>Antonia</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Nolla</LastName><ForeName>Joan</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Fernández</LastName><ForeName>Francisco</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>Cervelló</LastName><ForeName>Joaquim Ramón</ForeName><Initials>JR</Initials></Investigator><Investigator ValidYN="Y"><LastName>Iglesia</LastName><ForeName>Raquel</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Mañéz</LastName><ForeName>Rafael</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ballús</LastName><ForeName>J</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Granada</LastName><ForeName>Rosa Ma</ForeName><Initials>RM</Initials></Investigator><Investigator ValidYN="Y"><LastName>Vallés</LastName><ForeName>Jordi</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Díaz</LastName><ForeName>Emili</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ortíz</LastName><ForeName>Marta</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Guía</LastName><ForeName>C</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Martín-Loeches</LastName><ForeName>Ignacio</ForeName><Initials>I</Initials></Investigator><Investigator ValidYN="Y"><LastName>Páez</LastName><ForeName>Joaquim</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Almirall</LastName><ForeName>Jordi</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Balanzó</LastName><ForeName>Xavier</ForeName><Initials>X</Initials></Investigator><Investigator ValidYN="Y"><LastName>Güell</LastName><ForeName>Estel</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Yébenes</LastName><ForeName>Juan Carlos</ForeName><Initials>JC</Initials></Investigator><Investigator ValidYN="Y"><LastName>Rello</LastName><ForeName>Jordi</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Arnau</LastName><ForeName>Elena</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Pérez</LastName><ForeName>Marcos</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Laborda</LastName><ForeName>César</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Souto</LastName><ForeName>Jesica</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Lagunes</LastName><ForeName>Leonel</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Catalán</LastName><ForeName>Iñaki</ForeName><Initials>I</Initials></Investigator><Investigator ValidYN="Y"><LastName>Sirvent</LastName><ForeName>Josep Ma</ForeName><Initials>JM</Initials></Investigator><Investigator ValidYN="Y"><LastName>de Arbina</LastName><ForeName>Nerea López</ForeName><Initials>NL</Initials></Investigator><Investigator ValidYN="Y"><LastName>Serra</LastName><ForeName>Anna Baró</ForeName><Initials>AB</Initials></Investigator><Investigator ValidYN="Y"><LastName>Sánchez</LastName><ForeName>Adriana</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Cuenca</LastName><ForeName>Silvia M</ForeName><Initials>SM</Initials></Investigator><Investigator ValidYN="Y"><LastName>Badía</LastName><ForeName>Mariona</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Baseda-Garrido</LastName><ForeName>Begonia</ForeName><Initials>B</Initials></Investigator><Investigator ValidYN="Y"><LastName>Valverdú-Vidal</LastName><ForeName>Montserrat</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Barcenilla</LastName><ForeName>Fernando</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>Palomar</LastName><ForeName>Mercedes</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Nuvials</LastName><ForeName>Xavier</ForeName><Initials>X</Initials></Investigator><Investigator ValidYN="Y"><LastName>Benedicto</LastName><ForeName>Pedro Garrido</ForeName><Initials>PG</Initials></Investigator><Investigator ValidYN="Y"><LastName>Campo</LastName><ForeName>Ferrán Roche</ForeName><Initials>FR</Initials></Investigator><Investigator ValidYN="Y"><LastName>Esteban</LastName><ForeName>M F</ForeName><Initials>MF</Initials></Investigator><Investigator ValidYN="Y"><LastName>Luna</LastName><ForeName>José</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Eixarch</LastName><ForeName>Gaspar Masdeu</ForeName><Initials>GM</Initials></Investigator><Investigator ValidYN="Y"><LastName>Diago</LastName><ForeName>Angels Pascual</ForeName><Initials>AP</Initials></Investigator><Investigator ValidYN="Y"><LastName>Nava</LastName><ForeName>Juan Ma</ForeName><Initials>JM</Initials></Investigator><Investigator ValidYN="Y"><LastName>de Molina</LastName><ForeName>J González</ForeName><Initials>JG</Initials></Investigator><Investigator ValidYN="Y"><LastName>Trenado</LastName><ForeName>Josep</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ferrer</LastName><ForeName>Ricard</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Josic</LastName><ForeName>Zoran</ForeName><Initials>Z</Initials></Investigator><Investigator ValidYN="Y"><LastName>Casanovas</LastName><ForeName>Montserrat</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Gurri</LastName><ForeName>Francisco</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>Rodríguez</LastName><ForeName>Paula</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Rodríguez</LastName><ForeName>Alejandro</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Claverías</LastName><ForeName>Laura</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Trefler</LastName><ForeName>Sandra</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Bodí</LastName><ForeName>María</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Magret</LastName><ForeName>Mónica</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ferri</LastName><ForeName>Cristina</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Díaz</LastName><ForeName>Rosa María</ForeName><Initials>RM</Initials></Investigator><Investigator ValidYN="Y"><LastName>Mesalles</LastName><ForeName>Eduard</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Arméstar</LastName><ForeName>Fernando</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>de Mendoza</LastName><ForeName>Diego</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Fernández</LastName><ForeName>Carmen Lomas</ForeName><Initials>CL</Initials></Investigator><Investigator ValidYN="Y"><LastName>Berrade</LastName><ForeName>José Julián</ForeName><Initials>JJ</Initials></Investigator><Investigator ValidYN="Y"><LastName>Saris</LastName><ForeName>Alfonso Bonet</ForeName><Initials>AB</Initials></Investigator><Investigator ValidYN="Y"><LastName>Pechkova</LastName><ForeName>Marina</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Jiménez</LastName><ForeName>Cristina Mora</ForeName><Initials>CM</Initials></Investigator><Investigator ValidYN="Y"><LastName>Gil</LastName><ForeName>Santiago Picos</ForeName><Initials>SP</Initials></Investigator><Investigator ValidYN="Y"><LastName>José</LastName><ForeName>Juliá-Narváez</ForeName><Initials>JN</Initials></Investigator><Investigator ValidYN="Y"><LastName>Marcos</LastName><ForeName>Manuel Robles</ForeName><Initials>MR</Initials></Investigator><Investigator ValidYN="Y"><LastName>Mallqui</LastName><ForeName>Vanessa Farje</ForeName><Initials>VF</Initials></Investigator><Investigator ValidYN="Y"><LastName>Triviño</LastName><ForeName>Ma Ángeles Santiago</ForeName><Initials>MÁ</Initials></Investigator><Investigator ValidYN="Y"><LastName>García</LastName><ForeName>Pablo Martínez</ForeName><Initials>PM</Initials></Investigator><Investigator ValidYN="Y"><LastName>Fernández-Zapata</LastName><ForeName>Alberto</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Recio</LastName><ForeName>Teresa</ForeName><Initials>T</Initials></Investigator><Investigator ValidYN="Y"><LastName>Arrascaeta</LastName><ForeName>Abilio</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>García-Ramos</LastName><ForeName>Ma José</ForeName><Initials>MJ</Initials></Investigator><Investigator ValidYN="Y"><LastName>Gallego</LastName><ForeName>Elena</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Rodrigo</LastName><ForeName>Esther Saiz</ForeName><Initials>ES</Initials></Investigator><Investigator ValidYN="Y"><LastName>Bueno</LastName><ForeName>Fernando</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>Díaz</LastName><ForeName>Mercedes</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Pérez</LastName><ForeName>Noemí Gil</ForeName><Initials>NG</Initials></Investigator><Investigator ValidYN="Y"><LastName>Hormigo</LastName><ForeName>David López</ForeName><Initials>DL</Initials></Investigator><Investigator ValidYN="Y"><LastName>Delgado</LastName><ForeName>Juan Diego Jiménez</ForeName><Initials>JD</Initials></Investigator><Investigator ValidYN="Y"><LastName>Frutos</LastName><ForeName>Pérez</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Pinna</LastName><ForeName>M J Rivera</ForeName><Initials>MJ</Initials></Investigator><Investigator ValidYN="Y"><LastName>Cordero</LastName><ForeName>Ma Lourdes</ForeName><Initials>ML</Initials></Investigator><Investigator ValidYN="Y"><LastName>Pastor</LastName><ForeName>José A</ForeName><Initials>JA</Initials></Investigator><Investigator ValidYN="Y"><LastName>Álvarez-Rocha</LastName><ForeName>Luis</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Barros</LastName><ForeName>Alexandra Ceniceros</ForeName><Initials>AC</Initials></Investigator><Investigator ValidYN="Y"><LastName>Pedreira</LastName><ForeName>Alejandra Virgós</ForeName><Initials>AV</Initials></Investigator><Investigator ValidYN="Y"><LastName>Vila</LastName><ForeName>Dolores</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>González</LastName><ForeName>Carmen Fernández</ForeName><Initials>CF</Initials></Investigator><Investigator ValidYN="Y"><LastName>Merayo</LastName><ForeName>Eleuterio</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>López-Ciudad</LastName><ForeName>Víctor José</ForeName><Initials>VJ</Initials></Investigator><Investigator ValidYN="Y"><LastName>Cañones</LastName><ForeName>Juan Cortés</ForeName><Initials>JC</Initials></Investigator><Investigator ValidYN="Y"><LastName>Vilaboy</LastName><ForeName>Eva</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Chao</LastName><ForeName>José Villar</ForeName><Initials>JV</Initials></Investigator><Investigator ValidYN="Y"><LastName>López</LastName><ForeName>Francisco Savira Cid</ForeName><Initials>FS</Initials></Investigator><Investigator ValidYN="Y"><LastName>Cortés</LastName><ForeName>Pablo Vidal</ForeName><Initials>PV</Initials></Investigator><Investigator ValidYN="Y"><LastName>Veloso</LastName><ForeName>Marcos A Pérez</ForeName><Initials>MA</Initials></Investigator><Investigator ValidYN="Y"><LastName>Saborido</LastName><ForeName>Eva María</ForeName><Initials>EM</Initials></Investigator><Investigator ValidYN="Y"><LastName>Pardavila</LastName><ForeName>Enrique Alemparte</ForeName><Initials>EA</Initials></Investigator><Investigator ValidYN="Y"><LastName>Montes</LastName><ForeName>Ana Ortega</ForeName><Initials>AO</Initials></Investigator><Investigator ValidYN="Y"><LastName>González</LastName><ForeName>Raúl José</ForeName><Initials>RJ</Initials></Investigator><Investigator ValidYN="Y"><LastName>Freita</LastName><ForeName>Santiago</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Alemparte</LastName><ForeName>Enrique</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ortega</LastName><ForeName>Ana</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>López</LastName><ForeName>Ana María</ForeName><Initials>AM</Initials></Investigator><Investigator ValidYN="Y"><LastName>Canabal</LastName><ForeName>Julio</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ferres</LastName><ForeName>Enrique</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Pérez</LastName><ForeName>Javier Blanco</ForeName><Initials>JB</Initials></Investigator><Investigator ValidYN="Y"><LastName>Piquer</LastName><ForeName>M Ortiz</ForeName><Initials>MO</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ramos</LastName><ForeName>Santiago Freitas</ForeName><Initials>SF</Initials></Investigator><Investigator ValidYN="Y"><LastName>Cendón</LastName><ForeName>Lucas Lage</ForeName><Initials>LL</Initials></Investigator><Investigator ValidYN="Y"><LastName>Casal</LastName><ForeName>Vanesa Gómez</ForeName><Initials>VG</Initials></Investigator><Investigator ValidYN="Y"><LastName>Adrio</LastName><ForeName>Sabela Vara</ForeName><Initials>SV</Initials></Investigator><Investigator ValidYN="Y"><LastName>Fernández</LastName><ForeName>Eva Menor</ForeName><Initials>EM</Initials></Investigator><Investigator ValidYN="Y"><LastName>Prado</LastName><ForeName>Susana González</ForeName><Initials>SG</Initials></Investigator><Investigator ValidYN="Y"><LastName>Franco</LastName><ForeName>Antonio Varela</ForeName><Initials>AV</Initials></Investigator><Investigator ValidYN="Y"><LastName>Monzón</LastName><ForeName>José Luis</ForeName><Initials>JL</Initials></Investigator><Investigator ValidYN="Y"><LastName>Goñi</LastName><ForeName>Félix</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>Del Nogal Sáez</LastName><ForeName>Frutos</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>Navalpotro</LastName><ForeName>M Blasco</ForeName><Initials>MB</Initials></Investigator><Investigator ValidYN="Y"><LastName>Abad</LastName><ForeName>Ricardo Díaz</ForeName><Initials>RD</Initials></Investigator><Investigator ValidYN="Y"><LastName>Lasierra</LastName><ForeName>José Luis Flordelis</ForeName><Initials>JL</Initials></Investigator><Investigator ValidYN="Y"><LastName>García-Torrejón</LastName><ForeName>Ma Carmen</ForeName><Initials>MC</Initials></Investigator><Investigator ValidYN="Y"><LastName>Pérez-Calvo</LastName><ForeName>César</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>López</LastName><ForeName>Diego</ForeName><Initials>D</Initials></Investigator><Investigator ValidYN="Y"><LastName>Arnaiz</LastName><ForeName>Luis</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Sánchez-Alonso</LastName><ForeName>S</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Velayos</LastName><ForeName>Carlos</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Del Río</LastName><ForeName>Francisco</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>González</LastName><ForeName>Miguel Ángel</ForeName><Initials>MÁ</Initials></Investigator><Investigator ValidYN="Y"><LastName>Nieto</LastName><ForeName>Mercedes</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Cesteros</LastName><ForeName>Carmen Sánchez</ForeName><Initials>CS</Initials></Investigator><Investigator ValidYN="Y"><LastName>Martín</LastName><ForeName>María Cruz</ForeName><Initials>MC</Initials></Investigator><Investigator ValidYN="Y"><LastName>Molina</LastName><ForeName>José Ma</ForeName><Initials>JM</Initials></Investigator><Investigator ValidYN="Y"><LastName>Montejo</LastName><ForeName>Juan Carlos</ForeName><Initials>JC</Initials></Investigator><Investigator ValidYN="Y"><LastName>Catalán</LastName><ForeName>Mercedes</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Albert</LastName><ForeName>Patricia</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>de Pablo</LastName><ForeName>Ana</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Guerrero</LastName><ForeName>José Eugenio</ForeName><Initials>JE</Initials></Investigator><Investigator ValidYN="Y"><LastName>Zurita</LastName><ForeName>María</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Peyrat</LastName><ForeName>Jaime Benítez</ForeName><Initials>JB</Initials></Investigator><Investigator ValidYN="Y"><LastName>Cámara</LastName><ForeName>Miriam Díaz</ForeName><Initials>MD</Initials></Investigator><Investigator ValidYN="Y"><LastName>Cerdá</LastName><ForeName>Enrique</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Alvarez</LastName><ForeName>Manuel</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Pey</LastName><ForeName>Carlos</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Riestra</LastName><ForeName>Eva Manteiga</ForeName><Initials>EM</Initials></Investigator><Investigator ValidYN="Y"><LastName>Martínez-Fidalgo</LastName><ForeName>Concepción</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Rodríguez</LastName><ForeName>Montse</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Palencia</LastName><ForeName>Eduardo</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Caballero</LastName><ForeName>Rafael</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Vaquero</LastName><ForeName>Concepción</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Mariscal</LastName><ForeName>Francisco</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>García</LastName><ForeName>S</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Cepeda</LastName><ForeName>Rico</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Carrasco</LastName><ForeName>Nieves</ForeName><Initials>N</Initials></Investigator><Investigator ValidYN="Y"><LastName>Prieto</LastName><ForeName>Isidro</ForeName><Initials>I</Initials></Investigator><Investigator ValidYN="Y"><LastName>Liétor</LastName><ForeName>A</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ramos</LastName><ForeName>R</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Casas</LastName><ForeName>Rosario Cuadra</ForeName><Initials>RC</Initials></Investigator><Investigator ValidYN="Y"><LastName>Cuesta</LastName><ForeName>Cruz Soriano</ForeName><Initials>CS</Initials></Investigator><Investigator ValidYN="Y"><LastName>Alonso</LastName><ForeName>Susana Sánchez</ForeName><Initials>SS</Initials></Investigator><Investigator ValidYN="Y"><LastName>Galván</LastName><ForeName>Beatriz</ForeName><Initials>B</Initials></Investigator><Investigator ValidYN="Y"><LastName>Figueira</LastName><ForeName>Juan C</ForeName><Initials>JC</Initials></Investigator><Investigator ValidYN="Y"><LastName>Soriano</LastName><ForeName>M Cruz</ForeName><Initials>MC</Initials></Investigator><Investigator ValidYN="Y"><LastName>Martín</LastName><ForeName>Belen Civantos</ForeName><Initials>BC</Initials></Investigator><Investigator ValidYN="Y"><LastName>Caballero</LastName><ForeName>Alejandro Robles</ForeName><Initials>AR</Initials></Investigator><Investigator ValidYN="Y"><LastName>Galdós</LastName><ForeName>P</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Moreno</LastName><ForeName>Bárbara Balandín</ForeName><Initials>BB</Initials></Investigator><Investigator ValidYN="Y"><LastName>Carmona</LastName><ForeName>Sara Alcántara</ForeName><Initials>SA</Initials></Investigator><Investigator ValidYN="Y"><LastName>Del Cabo</LastName><ForeName>Fernández</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>Hermosa</LastName><ForeName>Cecilia</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Gordo</LastName><ForeName>Federico</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>Algora</LastName><ForeName>Alejandro</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Paredes</LastName><ForeName>Amparo</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Carmona</LastName><ForeName>Teodoro Grau</ForeName><Initials>TG</Initials></Investigator><Investigator ValidYN="Y"><LastName>Cambronero</LastName><ForeName>J A</ForeName><Initials>JA</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ramos</LastName><ForeName>Esther López</ForeName><Initials>EL</Initials></Investigator><Investigator ValidYN="Y"><LastName>de Zárate</LastName><ForeName>Yaiza Ortiz</ForeName><Initials>YO</Initials></Investigator><Investigator ValidYN="Y"><LastName>Gómez-Rosado</LastName><ForeName>Sonia</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Lodo</LastName><ForeName>Margarita Mas</ForeName><Initials>MM</Initials></Investigator><Investigator ValidYN="Y"><LastName>Garrobo</LastName><ForeName>Nieves Franco</ForeName><Initials>NF</Initials></Investigator><Investigator ValidYN="Y"><LastName>Hernández</LastName><ForeName>Silvia Álvarez</ForeName><Initials>SÁ</Initials></Investigator><Investigator ValidYN="Y"><LastName>Honrubia</LastName><ForeName>Teresa</ForeName><Initials>T</Initials></Investigator><Investigator ValidYN="Y"><LastName>López</LastName><ForeName>Luis Miguel Prado</ForeName><Initials>LM</Initials></Investigator><Investigator ValidYN="Y"><LastName>Lorente</LastName><ForeName>Esteban A</ForeName><Initials>EA</Initials></Investigator><Investigator ValidYN="Y"><LastName>Nin</LastName><ForeName>J A</ForeName><Initials>JA</Initials></Investigator><Investigator ValidYN="Y"><LastName>Sotomayor</LastName><ForeName>Carlos Jaramillo</ForeName><Initials>CJ</Initials></Investigator><Investigator ValidYN="Y"><LastName>Arnaiz</LastName><ForeName>Luis</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Silvero</LastName><ForeName>Esperanza Molero</ForeName><Initials>EM</Initials></Investigator><Investigator ValidYN="Y"><LastName>de la Reguera</LastName><ForeName>Eduardo Morales Fernández</ForeName><Initials>EM</Initials></Investigator><Investigator ValidYN="Y"><LastName>Monje</LastName><ForeName>Rosa Ma de la Casa</ForeName><Initials>RM</Initials></Investigator><Investigator ValidYN="Y"><LastName>Serrano</LastName><ForeName>Fátima Martín</ForeName><Initials>FM</Initials></Investigator><Investigator ValidYN="Y"><LastName>Martínez</LastName><ForeName>Ma Victoria Trasmonte</ForeName><Initials>MV</Initials></Investigator><Investigator ValidYN="Y"><LastName>Delgado</LastName><ForeName>M Cruz Martín</ForeName><Initials>MC</Initials></Investigator><Investigator ValidYN="Y"><LastName>Martínez</LastName><ForeName>Sofía</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Abad</LastName><ForeName>F Felices</ForeName><Initials>FF</Initials></Investigator><Investigator ValidYN="Y"><LastName>Navalon</LastName><ForeName>Isabel Cremades</ForeName><Initials>IC</Initials></Investigator><Investigator ValidYN="Y"><LastName>Velis</LastName><ForeName>Martín Vigil</ForeName><Initials>MV</Initials></Investigator><Investigator ValidYN="Y"><LastName>Martínez</LastName><ForeName>Mariano</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Baño</LastName><ForeName>Domingo Martínez</ForeName><Initials>DM</Initials></Investigator><Investigator ValidYN="Y"><LastName>Andreu</LastName><ForeName>Enriqueta</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Butí</LastName><ForeName>Sergio Manuel</ForeName><Initials>SM</Initials></Investigator><Investigator ValidYN="Y"><LastName>Rueda</LastName><ForeName>Bernardo Gil</ForeName><Initials>BG</Initials></Investigator><Investigator ValidYN="Y"><LastName>García</LastName><ForeName>Francisco</ForeName><Initials>F</Initials></Investigator><Investigator ValidYN="Y"><LastName>Fernández</LastName><ForeName>Noemí Llamas</ForeName><Initials>NL</Initials></Investigator><Investigator ValidYN="Y"><LastName>Para</LastName><ForeName>Luis Herrera</ForeName><Initials>LH</Initials></Investigator><Investigator ValidYN="Y"><LastName>Freire</LastName><ForeName>Alejandro Ortín</ForeName><Initials>AO</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ruiz</LastName><ForeName>Ma Rosa Navarro</ForeName><Initials>MR</Initials></Investigator><Investigator ValidYN="Y"><LastName>Romero</LastName><ForeName>C R Hernández</ForeName><Initials>CR</Initials></Investigator><Investigator ValidYN="Y"><LastName>Maraví-Poma</LastName><ForeName>Enrique</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Urra</LastName><ForeName>I Jimenez</ForeName><Initials>IJ</Initials></Investigator><Investigator ValidYN="Y"><LastName>Redin</LastName><ForeName>Laura Macaya</ForeName><Initials>LM</Initials></Investigator><Investigator ValidYN="Y"><LastName>Tellería</LastName><ForeName>A</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Insausti</LastName><ForeName>Josu</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>García</LastName><ForeName>Noelia Artesero</ForeName><Initials>NA</Initials></Investigator><Investigator ValidYN="Y"><LastName>Macaya</LastName><ForeName>Laura</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Palanco</LastName><ForeName>Joaquín Lobo</ForeName><Initials>JL</Initials></Investigator><Investigator ValidYN="Y"><LastName>González</LastName><ForeName>Nagore</ForeName><Initials>N</Initials></Investigator><Investigator ValidYN="Y"><LastName>Marco</LastName><ForeName>Pilar</ForeName><Initials>P</Initials></Investigator><Investigator ValidYN="Y"><LastName>Vidaur</LastName><ForeName>Loreto</ForeName><Initials>L</Initials></Investigator><Investigator ValidYN="Y"><LastName>Salas</LastName><ForeName>Estibaliz</ForeName><Initials>E</Initials></Investigator><Investigator ValidYN="Y"><LastName>Udabe</LastName><ForeName>Ruth Salaberría</ForeName><Initials>RS</Initials></Investigator><Investigator ValidYN="Y"><LastName>Santamaría</LastName><ForeName>B</ForeName><Initials>B</Initials></Investigator><Investigator ValidYN="Y"><LastName>Rodríguez</LastName><ForeName>Tomás</ForeName><Initials>T</Initials></Investigator><Investigator ValidYN="Y"><LastName>Vergara</LastName><ForeName>Juan Carlos</ForeName><Initials>JC</Initials></Investigator><Investigator ValidYN="Y"><LastName>Amiano</LastName><ForeName>Jose Ramón Iruretagoyena</ForeName><Initials>JR</Initials></Investigator><Investigator ValidYN="Y"><LastName>Santos</LastName><ForeName>Iratí Garrido</ForeName><Initials>IG</Initials></Investigator><Investigator ValidYN="Y"><LastName>Manzano</LastName><ForeName>Alberto</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Arenal</LastName><ForeName>Carlos Castillo</ForeName><Initials>CC</Initials></Investigator><Investigator ValidYN="Y"><LastName>Olaechea</LastName><ForeName>Pedro María</ForeName><Initials>PM</Initials></Investigator><Investigator ValidYN="Y"><LastName>Hernández</LastName><ForeName>Higinio Martín</ForeName><Initials>HM</Initials></Investigator><Investigator ValidYN="Y"><LastName>López</LastName><ForeName>Alejandro Martín</ForeName><Initials>AM</Initials></Investigator><Investigator ValidYN="Y"><LastName>Miguel</LastName><ForeName>Fernando Fonseca San</ForeName><Initials>FF</Initials></Investigator><Investigator ValidYN="Y"><LastName>Blanquer</LastName><ForeName>José</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Carbonell</LastName><ForeName>Nieves</ForeName><Initials>N</Initials></Investigator><Investigator ValidYN="Y"><LastName>Franco</LastName><ForeName>José Ferreres</ForeName><Initials>JF</Initials></Investigator><Investigator ValidYN="Y"><LastName>Valero</LastName><ForeName>Roberto Reig</ForeName><Initials>RR</Initials></Investigator><Investigator ValidYN="Y"><LastName>Belenger</LastName><ForeName>A</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Altaba</LastName><ForeName>Susana</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Álvarez-Sánchez</LastName><ForeName>Bernabé</ForeName><Initials>B</Initials></Investigator><Investigator ValidYN="Y"><LastName>Robles</LastName><ForeName>José Cánovas</ForeName><Initials>JC</Initials></Investigator><Investigator ValidYN="Y"><LastName>Francisco</LastName><ForeName>Jaime Sánchez</ForeName><Initials>JS</Initials></Investigator><Investigator ValidYN="Y"><LastName>Sánchez</LastName><ForeName>Mar Ruiz</ForeName><Initials>MR</Initials></Investigator><Investigator ValidYN="Y"><LastName>Picos</LastName><ForeName>Santiago Alberto</ForeName><Initials>SA</Initials></Investigator><Investigator ValidYN="Y"><LastName>Llanes</LastName><ForeName>Abilio Arrascaeta</ForeName><Initials>AA</Initials></Investigator><Investigator ValidYN="Y"><LastName>Gutiérrez</LastName><ForeName>Eugenio Herrero</ForeName><Initials>EH</Initials></Investigator><Investigator ValidYN="Y"><LastName>Zapata</LastName><ForeName>Alberto Fernández</ForeName><Initials>AF</Initials></Investigator><Investigator ValidYN="Y"><LastName>Sánchez-Miralles</LastName><ForeName>Ángel</ForeName><Initials>Á</Initials></Investigator><Investigator ValidYN="Y"><LastName>Pascual</LastName><ForeName>José Luis Antón</ForeName><Initials>JL</Initials></Investigator><Investigator ValidYN="Y"><LastName>Bonastre</LastName><ForeName>Juan</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Palamo</LastName><ForeName>M</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Cebrián</LastName><ForeName>Javier</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Cuñat</LastName><ForeName>José</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Sahuquillo</LastName><ForeName>Mónica Gordón</ForeName><Initials>MG</Initials></Investigator><Investigator ValidYN="Y"><LastName>Romero</LastName><ForeName>Belén</ForeName><Initials>B</Initials></Investigator><Investigator ValidYN="Y"><LastName>Pallé</LastName><ForeName>Santiago Borrás</ForeName><Initials>SB</Initials></Investigator><Investigator ValidYN="Y"><LastName>de León Belmar</LastName><ForeName>Javier</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>Zaragoza</LastName><ForeName>Rafael</ForeName><Initials>R</Initials></Investigator><Investigator ValidYN="Y"><LastName>Tormo</LastName><ForeName>Constantino</ForeName><Initials>C</Initials></Investigator><Investigator ValidYN="Y"><LastName>Chinesta</LastName><ForeName>Susana Sancho</ForeName><Initials>SS</Initials></Investigator><Investigator ValidYN="Y"><LastName>Paricio</LastName><ForeName>Virgilio</ForeName><Initials>V</Initials></Investigator><Investigator ValidYN="Y"><LastName>Marqués</LastName><ForeName>Asunción</ForeName><Initials>A</Initials></Investigator><Investigator ValidYN="Y"><LastName>Sánchez-Morcillo</LastName><ForeName>S</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Tormo</LastName><ForeName>S</ForeName><Initials>S</Initials></Investigator><Investigator ValidYN="Y"><LastName>Latour</LastName><ForeName>J</ForeName><Initials>J</Initials></Investigator><Investigator ValidYN="Y"><LastName>García</LastName><ForeName>M Ángel</ForeName><Initials>MÁ</Initials></Investigator><Investigator ValidYN="Y"><LastName>Palomo</LastName><ForeName>Manuel</ForeName><Initials>M</Initials></Investigator><Investigator ValidYN="Y"><LastName>Royo</LastName><ForeName>Francisco Tarín</ForeName><Initials>FT</Initials></Investigator><Investigator ValidYN="Y"><LastName>Hinojosa</LastName><ForeName>Pedro Manzano</ForeName><Initials>PM</Initials></Investigator><Investigator ValidYN="Y"><LastName>Pino</LastName><ForeName>Ma Salomé Sánchez</ForeName><Initials>MS</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ribes</LastName><ForeName>Concha Maragues</ForeName><Initials>CM</Initials></Investigator><Investigator ValidYN="Y"><LastName>Luis</LastName><ForeName>Rubén González</ForeName><Initials>RG</Initials></Investigator><Investigator ValidYN="Y"><LastName>Ribas</LastName><ForeName>Antolí</ForeName><Initials>A</Initials></Investigator></InvestigatorList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>07</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>09</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>10</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2018</Year><Month>3</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>10</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27770828</ArticleId><ArticleId IdType="doi">10.1186/s13054-016-1512-1</ArticleId><ArticleId IdType="pii">10.1186/s13054-016-1512-1</ArticleId><ArticleId IdType="pmc">PMC5075413</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>N Engl J Med. 2009 Dec 24;361(26):2507-17</Citation><ArticleIdList><ArticleId IdType="pubmed">20007555</ArticleId></ArticleIdList></Reference><Reference><Citation>J Am Geriatr Soc. 2013 Mar;61(3):350-6</Citation><ArticleIdList><ArticleId IdType="pubmed">23496351</ArticleId></ArticleIdList></Reference><Reference><Citation>BMC Infect Dis. 2015 Dec 18;15:573</Citation><ArticleIdList><ArticleId IdType="pubmed">26678835</ArticleId></ArticleIdList></Reference><Reference><Citation>Pediatr Emerg Care. 2013 Jan;29(1):49-52</Citation><ArticleIdList><ArticleId IdType="pubmed">23283263</ArticleId></ArticleIdList></Reference><Reference><Citation>Crit Care. 2011;15(6):R286</Citation><ArticleIdList><ArticleId IdType="pubmed">22126648</ArticleId></ArticleIdList></Reference><Reference><Citation>Med Intensiva. 2012 Mar;36(2):103-37</Citation><ArticleIdList><ArticleId IdType="pubmed">22245450</ArticleId></ArticleIdList></Reference><Reference><Citation>J Emerg Med. 2016 Mar;50(3):536-42</Citation><ArticleIdList><ArticleId IdType="pubmed">26763858</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Microbiol Infect. 2013 Mar;19(3):249-56</Citation><ArticleIdList><ArticleId IdType="pubmed">22404211</ArticleId></ArticleIdList></Reference><Reference><Citation>Obes Rev. 2011 Aug;12(8):653-9</Citation><ArticleIdList><ArticleId IdType="pubmed">21457180</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS One. 2014 Jul 08;9(7):e101785</Citation><ArticleIdList><ArticleId IdType="pubmed">25004134</ArticleId></ArticleIdList></Reference><Reference><Citation>Enferm Infecc Microbiol Clin. 2016 Mar;34(3):177-83</Citation><ArticleIdList><ArticleId IdType="pubmed">26025480</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Infect Dis. 2007 Mar 1;44 Suppl 2:S27-72</Citation><ArticleIdList><ArticleId IdType="pubmed">17278083</ArticleId></ArticleIdList></Reference><Reference><Citation>Indian J Pediatr. 2009 Aug;76(8):833-41</Citation><ArticleIdList><ArticleId IdType="pubmed">19802552</ArticleId></ArticleIdList></Reference><Reference><Citation>Crit Care Med. 2011 Sep;39(9):2066-71</Citation><ArticleIdList><ArticleId IdType="pubmed">21572327</ArticleId></ArticleIdList></Reference><Reference><Citation>Crit Care Med. 2011 May;39(5):945-51</Citation><ArticleIdList><ArticleId IdType="pubmed">21263317</ArticleId></ArticleIdList></Reference><Reference><Citation>Enferm Infecc Microbiol Clin. 2012 Dec;30(10):608-12</Citation><ArticleIdList><ArticleId IdType="pubmed">22459686</ArticleId></ArticleIdList></Reference><Reference><Citation>Intensive Care Med. 1996 Jul;22(7):707-10</Citation><ArticleIdList><ArticleId IdType="pubmed">8844239</ArticleId></ArticleIdList></Reference><Reference><Citation>Crit Care. 2009;13(5):R148</Citation><ArticleIdList><ArticleId IdType="pubmed">19747383</ArticleId></ArticleIdList></Reference><Reference><Citation>J Infect. 2012 Mar;64(3):311-8</Citation><ArticleIdList><ArticleId IdType="pubmed">22240033</ArticleId></ArticleIdList></Reference><Reference><Citation>Chin Med J (Engl). 2013 Jun;126(12):2222-8</Citation><ArticleIdList><ArticleId IdType="pubmed">23786929</ArticleId></ArticleIdList></Reference><Reference><Citation>Med Intensiva. 2011 May;35(4):208-16</Citation><ArticleIdList><ArticleId IdType="pubmed">21496964</ArticleId></ArticleIdList></Reference><Reference><Citation>Crit Care Med. 2014 Aug;42(8):1749-55</Citation><ArticleIdList><ArticleId IdType="pubmed">24717459</ArticleId></ArticleIdList></Reference><Reference><Citation>Crit Care. 2009;13(6):428; author reply 428</Citation><ArticleIdList><ArticleId IdType="pubmed">20067602</ArticleId></ArticleIdList></Reference><Reference><Citation>J Infect Dis. 2015 Oct 15;212(8):1200-8</Citation><ArticleIdList><ArticleId IdType="pubmed">25821227</ArticleId></ArticleIdList></Reference><Reference><Citation>Epidemiology. 2009 May;20(3):344-7</Citation><ArticleIdList><ArticleId IdType="pubmed">19279492</ArticleId></ArticleIdList></Reference><Reference><Citation>Intensive Care Med. 2013 Apr;39(4):693-702</Citation><ArticleIdList><ArticleId IdType="pubmed">23344833</ArticleId></ArticleIdList></Reference><Reference><Citation>J Antimicrob Chemother. 2011 May;66(5):1140-9</Citation><ArticleIdList><ArticleId IdType="pubmed">21385717</ArticleId></ArticleIdList></Reference><Reference><Citation>Crit Care Med. 2013 Feb;41(2):580-637</Citation><ArticleIdList><ArticleId IdType="pubmed">23353941</ArticleId></ArticleIdList></Reference><Reference><Citation>Indian J Gastroenterol. 2014 Mar;33(2):178-82</Citation><ArticleIdList><ArticleId IdType="pubmed">24470044</ArticleId></ArticleIdList></Reference><Reference><Citation>Epidemiol Infect. 2011 Sep;139(9):1418-24</Citation><ArticleIdList><ArticleId IdType="pubmed">21087539</ArticleId></ArticleIdList></Reference><Reference><Citation>Crit Care Med. 2015 Sep;43(9):1907-15</Citation><ArticleIdList><ArticleId IdType="pubmed">26121073</ArticleId></ArticleIdList></Reference><Reference><Citation>Crit Care Med. 1985 Oct;13(10):818-29</Citation><ArticleIdList><ArticleId IdType="pubmed">3928249</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Espagne</li><li>Irlande (pays)</li></country><region><li>Catalogne</li><li>Communauté de Madrid</li></region><settlement><li>Barcelone</li><li>Madrid</li></settlement><orgName><li>Université Pompeu Fabra</li><li>Université autonome de Barcelone</li></orgName></list><tree><country name="Espagne"><region name="Catalogne"><name sortKey="Alvarez Lerma, Francisco" sort="Alvarez Lerma, Francisco" uniqKey="Alvarez Lerma F" first="Francisco" last="Álvarez-Lerma">Francisco Álvarez-Lerma</name></region><name sortKey="Alvarez Lerma, Francisco" sort="Alvarez Lerma, Francisco" uniqKey="Alvarez Lerma F" first="Francisco" last="Álvarez-Lerma">Francisco Álvarez-Lerma</name><name sortKey="Alvarez Lerma, Francisco" sort="Alvarez Lerma, Francisco" uniqKey="Alvarez Lerma F" first="Francisco" last="Álvarez-Lerma">Francisco Álvarez-Lerma</name><name sortKey="Barbadillo, Sandra" sort="Barbadillo, Sandra" uniqKey="Barbadillo S" first="Sandra" last="Barbadillo">Sandra Barbadillo</name><name sortKey="Gonzalez De Molina, Francisco Javier" sort="Gonzalez De Molina, Francisco Javier" uniqKey="Gonzalez De Molina F" first="Francisco Javier" last="González De Molina">Francisco Javier González De Molina</name><name sortKey="Marin Corral, Judith" sort="Marin Corral, Judith" uniqKey="Marin Corral J" first="Judith" last="Marín-Corral">Judith Marín-Corral</name><name sortKey="Marin Corral, Judith" sort="Marin Corral, Judith" uniqKey="Marin Corral J" first="Judith" last="Marín-Corral">Judith Marín-Corral</name><name sortKey="Masclans, Joan Ram N" sort="Masclans, Joan Ram N" uniqKey="Masclans J" first="Joan Ram N" last="Masclans">Joan Ram N Masclans</name><name sortKey="Masclans, Joan Ram N" sort="Masclans, Joan Ram N" uniqKey="Masclans J" first="Joan Ram N" last="Masclans">Joan Ram N Masclans</name><name sortKey="Masclans, Joan Ram N" sort="Masclans, Joan Ram N" uniqKey="Masclans J" first="Joan Ram N" last="Masclans">Joan Ram N Masclans</name><name sortKey="Masclans, Joan Ram N" sort="Masclans, Joan Ram N" uniqKey="Masclans J" first="Joan Ram N" last="Masclans">Joan Ram N Masclans</name><name sortKey="Rodriguez, Alejandro" sort="Rodriguez, Alejandro" uniqKey="Rodriguez A" first="Alejandro" last="Rodríguez">Alejandro Rodríguez</name><name sortKey="Rodriguez, Alejandro" sort="Rodriguez, Alejandro" uniqKey="Rodriguez A" first="Alejandro" last="Rodríguez">Alejandro Rodríguez</name><name sortKey="Vila, Clara" sort="Vila, Clara" uniqKey="Vila C" first="Clara" last="Vila">Clara Vila</name></country><country name="Irlande (pays)"><noRegion><name sortKey="Martin Loeches, Ignacio" sort="Martin Loeches, Ignacio" uniqKey="Martin Loeches I" first="Ignacio" last="Martín Loeches">Ignacio Martín Loeches</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/GrippeEspagneV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000157 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000157 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= GrippeEspagneV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:27770828
|texte= Delay in diagnosis of influenza A (H1N1)pdm09 virus infection in critically ill patients and impact on clinical outcome.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:27770828" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a GrippeEspagneV1
| This area was generated with Dilib version V0.6.37. |  |